β-thujaplicin （CAS # 499-44-5)

Umutungo wa Shimi:

Inzira ya molekulari	C10H12O2
Misa	164.2
Ubucucike	1.0041 (igereranya)
Ingingo yo gushonga	50-52 ° C (lit.)
Ingingo ya Boling	140 ° C10mm Hg (lit.)
Flash point	128.1 ° C.
Gukemura	Kudashonga mumazi
Umwuka	8.98E-05mmHg kuri 25 ° C.
Kugaragara	Ibara ritagira ibara, prismatike ya kristu (yongeye gushyirwaho kuva Ethanol ya anhydrous)
Ibara	Cyera
Merk	14,9390
pKa	7.06 ± 0.30 (Byahanuwe)
Imiterere y'Ububiko	Ikidodo cyumye, Ubushyuhe bwicyumba
Igihagararo	Ihamye kumwaka 1 uhereye umunsi waguze nkuko byatanzwe. Ibisubizo muri DMSO cyangwa Ethanol birashobora kubikwa kuri -20 ° mugihe cyamezi 4.
Yumva	Irinde guhura na oxyde
Ironderero	1.5190 (igereranya)
MDL	MFCD00059582
Mu bushakashatsi bwa vitro	Muri U87MG na T98G imirongo ya selile ya glioma, hinokitiol yerekana igabanuka ryatewe nigabanuka ryimibereho, hamwe na IC 50 agaciro ka 316.5 ± 35.5 na 152.5 ± 25.3 µM. Hinokitiol ihagarika ibikorwa bya ALDH nubushobozi bwo kwiyubaka muri selile stem glioma, ikanabuza vitro oncogenicity. Hinokitiol kandi igabanya imvugo ya Nrf2 muri selile glioma stem muburyo butandukanye. Hinokitiol (0-100 μM) ibuza gukura kanseri ya kanseri y'amara mu buryo bukabije kandi bushingiye ku gihe. Hinokitiol (5, 10 μM) igabanya DNMT1 na UHRF1 mRNA hamwe na proteyine, kandi ikongera imvugo ya TET1 ikoresheje kuzamura urwego rwa 5hmC muri selile HCT-116. Byongeye kandi, hinokitiol igabanya imiterere ya methylation kandi igarura mRNA imvugo ya MGMT, CHST10, na BTG4.

Ohereza imeri kuri twe

Ibicuruzwa birambuye

Ibicuruzwa

Ibimenyetso bya Hazard	Xn - Byangiza
Kode y'ingaruka	22 - Byangiza iyo bimizwe
Ibisobanuro byumutekano	36 - Kwambara imyenda ikingira.
WGK Ubudage	3
RTECS	GU4200000

Intangiriro

Hinokiol, izwi kandi ku izina rya α-terpene inzoga cyangwa Thujanol, ni ibinyabuzima kama kama kama kamwe mubice bigize turpentine. Hinoylol ni ibara ritagira ibara, rifite umucyo ufite uburyohe bwa pinusi.

Hinokiol ifite imikoreshereze itandukanye. Ikoreshwa cyane mubikorwa bya parufe nimpumuro nziza kugirango hongerwe impumuro nziza nimpumuro nziza kubicuruzwa. Icya kabiri, inzoga zo mu bwoko bwa juniper nazo zikoreshwa nka fungiside no kubungabunga ibidukikije, kandi zikoreshwa kenshi mugutegura imiti yica udukoko na fungicide.

Hariho uburyo bwinshi bwo gutegura juniperol. Mubisanzwe, irashobora gukururwa no gusibanganya amavuta ahindagurika mumababi yimibabi cyangwa ibindi bimera bya cypress, hanyuma bigatandukanywa kandi bigasukurwa kugirango bibone juniperol. Inzoga ya Hinoki irashobora kandi guhuzwa na synthesis.

Amakuru yumutekano ya juniperol: Ntabwo ari uburozi kandi mubisanzwe bifatwa nkumutekano. Nkibintu kama, biracyakenewe gukemurwa no kubikwa neza. Irinde guhura nuruhu namaso, hanyuma uhite woza amazi mugihe uhuye nimpanuka. Igomba kubikwa kure yumuriro nubushyuhe bwinshi, ikabikwa ahantu hakonje, humye.

Mbere: Z-ASP-OBZL （CAS # 4779-31-1)

Ibikurikira: 3- (Trifluoromethoxy) benzyl bromide （CAS # 50824-05-0)

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