2-Chloro-3-fluoro-6-picoline （CAS # 374633-32-6)

Intangiriro

Kugaragara: Mubisanzwe bitagira ibara ryijimye ryumuhondo, iyi miterere iranga yerekana ko ishobora kuba yumva urumuri nubushyuhe, kandi birakenewe ko hafatwa ingamba zo kwirinda kugenzura ubushyuhe nubushyuhe mugihe cyo kubika no gutwara, nko gukoresha amacupa yikirahure yijimye no kubibika. mububiko bukonje kugirango wirinde irindi bara ryimbitse no kwangirika.

Gukemura: Urusange rufite imbaraga zo gukemura neza mumashanyarazi asanzwe, nka toluene na dichloromethane, ikurikiza ihame ryo gukemuka bisa, kandi ifitanye isano numuti ukomoka kumubiri bitewe nigice cya hydrophobique ya molekile; Nyamara, gukomera kwamazi ni muke, kandi guhuza hydrogène ikomeye hagati ya molekile zamazi biragoye kumeneka neza na molekile, bigatuma kuyikwirakwiza bigoye.
Ingingo yo gutekesha hamwe n'ubucucike: Amakuru yo guteka afitanye isano rya bugufi nihindagurika ryayo kandi irashobora gutanga ibipimo byingenzi mubikorwa nko gusibanganya no kweza, ariko ikibabaje nuko agaciro kihariye ko guteka katigeze kamenyekana cyane. Ubucucike bwabwo buri hejuru cyane y’amazi, kandi gusobanukirwa ubucucike burashobora gufasha kugereranya neza isano-nini yo guhinduranya ingano mubikorwa byubushakashatsi cyangwa mubikorwa byinganda nko guhererekanya amazi no gupima neza.
Imiterere yimiti
Igisubizo cyo gusimbuza: Atome ya chlorine na atome ya fluor muri molekile ni ahantu hashobora kuba reaction. Mubisubizo byo gusimbuza nucleophilique, nucleophile ikomeye irashobora kwibasira aho atome ya chlorine na fluor iherereye, igasimbuza atome ihuye, kandi ikabyara inkomoko nshya ya pyridine. Kurugero, rwahujwe na azote irimo azote na sulforo irimo nucleophile kugirango habeho urukurikirane rwibintu bya azote birimo heterocyclic hamwe nuburyo bugoye bwo kuvumbura ibiyobyabwenge cyangwa synthesis.
Redox reaction: impeta ya pyridine ubwayo irahagaze neza, ariko iyo okiside ikomeye, nka potasiyumu permanganate na hydrogen peroxide ihujwe na acide, okiside irashobora kubaho, bikaviramo gusenya cyangwa guhindura imiterere yimpeta ya pyridine; Ibinyuranye, hamwe nuburyo bukwiye bwo kugabanya, nka hydride yicyuma, birashoboka muburyo bwa hydrogène ya hydrogène yimitsi idahagije.
Icya kane, uburyo bwa synthesis
Inzira isanzwe ya synthesis nugutangirira kubikomoka kuri pyridine yoroshye hanyuma ugahindura buhoro buhoro imiterere yintego binyuze muri halogenation na fluor reaction. Ibikoresho byo gutangiza pyridine byabanje guhitamo methylated hamwe na methyl matsinda yatangijwe icyarimwe; Noneho koresha reagent ya halogenation, nka chlorine na chlorine y'amazi, hamwe na catalizator ikwiye hamwe nuburyo bwo kubyitwaramo, kugirango ugere kuri atome ya chlorine; Hanyuma, reagent ya fluor, nka Selectfluor, yakoreshejwe muguhindura neza urubuga rwerekanwe kugirango haboneke 2-chloro-3-fluoro-6-methylpyridine.
Gukoresha
Guhuza ibiyobyabwenge bihuza: imiterere yihariye ikundwa naba chimiste, kandi ni intera yo mu rwego rwo hejuru yo guteza imbere imiti mishya ya antibacterial, antiviral, na antitumor. Imiterere ya elegitoronike nuburyo butandukanye bwimpeta ya pyridine ninsimburangingo zishobora guhuza cyane na poroteyine zigenewe muri vivo, kandi biteganijwe ko zizahinduka mubintu bikora neza hamwe nibikorwa byiza nyuma yo guhindura intambwe nyinshi.
Siyanse y'ibikoresho: Mu rwego rwo guhuza ibikoresho kama, irashobora gukoreshwa mugukora ibikoresho bya polymer bikora, ibikoresho bya fluorescente, nibindi, bitewe nubushobozi bwayo bwo kumenyekanisha neza chlorine, atome ya fluor nuburyo bwa pyridine, guha ibikoresho ibikoresho byamashanyarazi bidasanzwe na optique imitungo, no guteza imbere iterambere rya tekinoroji igezweho nkibikoresho byubwenge nibikoresho byerekana.