2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS # 865363-93-5)
Kumenyekanisha 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), igereranya nucleoside igereranya igamije guhindura urwego rwibinyabuzima bya molekuline nubushakashatsi bwa farumasi. Uru ruganda rudasanzwe rwashizweho kugirango rutezimbere gusobanukirwa n’imikoranire ya aside nucleique hamwe ningirabuzimafatizo, bituma iba igikoresho ntagereranywa kubashakashatsi n'abahanga.
2′-Deoxy-4′-C-Ethynyl-2-fluoroadenosine irangwa nuburyo bwihariye bwo guhindura imiterere, burimo insimburangingo ya Ethynyl na fluor kumwanya wa 4 ′ na 2 ′. Izi mpinduka ntabwo zitezimbere gusa urwego rwimiterere nubuzima bwa bioavailable ahubwo binongerera ubushobozi bwo kwinjira mumyanya ndangagitsina, bigatuma habaho gutanga neza no gufata neza muburyo butandukanye bwibinyabuzima.
Ikigereranyo cya nucleoside cyerekanye ubushobozi butanga imbaraga mubikorwa bitandukanye, harimo ubushakashatsi bwa antiviral na anticancer. Ubushobozi bwayo bwo kwigana nucleoside karemano mugihe hagaragajwe imiterere ya biohimiki ituma iba umukandida mwiza mugutezimbere imiti ivura imiti. Abashakashatsi barashobora gukoresha 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine kugira ngo bige synthesis ya RNA na ADN, bakore iperereza ku mikoranire ya enzyme, kandi banashakishe uburyo bwo gukora ibiyobyabwenge bihari.
Usibye ubushakashatsi bwakozwe, iyi nteruro nayo yiteguye kugira uruhare runini mugutezimbere ibisekuruza bizaza. Mugutanga ubushishozi kumyitwarire ya acide nucleic n'imikoranire, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine irashobora gufasha mugutegura uburyo bunoze kandi bugamije kuvura indwara zitandukanye.
Muri make, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) nikigereranyo cya nucleoside igereranya itanga amahirwe atagereranywa yubushakashatsi niterambere muri biologiya ya molekuline na farumasi. Emera ahazaza havumbuwe siyanse hamwe niyi nteruro idasanzwe kandi ufungure ibishoboka bishya mubikorwa byubushakashatsi.
