2,4,5-Acide ya Trifluorophenylacetic (CAS # 209995-38-0)
Gusaba
2,4, 5-trifluorophenylacetic aside nikintu cyera gikoreshwa muguhuza imiti mishya ya sitagliptine yo kuvura diyabete yo mu bwoko bwa II. sitagliptin niyambere DPP-IV inhibitor iherutse gutondekwa na Merck. Ifite ingaruka nziza zo kuvura, ingaruka ntoya, umutekano mwiza no kwihanganira kuvura diyabete yo mu bwoko bwa II, kandi ifite isoko ryagutse.
Ibisobanuro
Kugaragara Kugaragara
Ibara ryera kugeza hanze-yera
pKa 3.78 ± 0.10 (Biteganijwe)
Imiterere y'Ububiko Ifunze mu cyuma, Ubushyuhe bw'icyumba
Igipimo cyerekana 1.488
Umutekano
Ibimenyetso bya Hazard Xi - Kurakara
Kurakara
Kode y'ibyago R37 / 38 - Kurakaza sisitemu y'ubuhumekero n'uruhu.
R41 - Ibyago byo kwangirika cyane kumaso
Umutekano Ibisobanuro S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushake inama kubaganga.
S39 - Kwambara ijisho / kurinda amaso.
WGK Ubudage 3
HS Kode 29163990
Icyiciro cya Hazard IRRITANT
Gupakira & Ububiko
Gupakirwa mu ngoma 25kg / 50kg. Komeza ahantu hijimye, Gufunzwe byumye, Ubushyuhe bwicyumba
Intangiriro
Kumenyekanisha Acide 2,4,5-Trifluorophenylacetic Acide, igiti cyera gikoreshwa cyane munganda zimiti muguhuza sitagliptin abahuza kuvura diyabete yo mu bwoko bwa II.
Nka kimwe mu bintu byingenzi mu gukora sitagliptine, 2,4,5-Acide ya Trifluorophenylacetic yagize uruhare runini mu iterambere ry’ibi biyobyabwenge. Sitagliptin ninzitizi ya DPP-IV iheruka gushyirwa ku rutonde na Merck. Irata ingaruka nziza zo kuvura, ingaruka mbi nkeya, umutekano no kwihanganira, kandi yahindutse ibiyobyabwenge mu kuvura diyabete yo mu bwoko bwa II.
Imwe mu nyungu zingenzi za 2,4,5-Trifluorophenylacetic Acide ni uko ituma umusaruro wa sitagliptine uhendutse ugereranije, bigatuma abantu benshi babona iyi miti ihindura ubuzima. Byongeye kandi, bifite akamaro kanini mukuvura diyabete kandi bitanga ibyiringiro bishya kubahanganye niyi ndwara.
Kugaragara kwa Acide 2,4,5-Trifluorophenylacetic Acide ni kristaline yera kugeza ifu yera, byoroshye kumenya, gufata, no gutwara. Irahagaze neza kandi mubihe bisanzwe, bivuze ko ishobora kubikwa igihe kirekire nta gutesha agaciro.
2,4,5-Trifluorophenylacetic Acide irahuza cyane kandi irashobora gukoreshwa muguhuza ibindi bintu bigoye birenze sitagliptin. Ifite inganda zitandukanye zikoreshwa mu nganda, harimo n’umusaruro w’ubuhinzi-mwimerere, ibisigazwa, n’umuhuza. Irashobora kandi gukoreshwa nkibikoresho byo gutangiza synthesis ya intera nini ya molekile hamwe nibisabwa bitandukanye.
Muri sosiyete yacu, twishimiye kuba twatanze Acide nziza-2,4,5-Trifluorophenylacetic Acide kubakiriya bacu. Ibicuruzwa byacu byujuje ubuziranenge bwo hejuru kandi bikozwe bikurikiza amabwiriza akomeye kugirango habeho guhuzagurika no kwera.
Mu gusoza, Acide 2,4,5-Trifluorophenylacetic Acide ningirakamaro cyane yahindutse ikintu cyingenzi mugukora sitagliptine, imiti yo kumurongo wa mbere ya diyabete yo mu bwoko bwa II. Guhindura byinshi no gukora neza bigira umutungo w'agaciro mu nganda zimiti n’imiti, kandi twishimiye gutanga Acide nziza cyane 2,4,5-Trifluorophenylacetic Acide kubakiriya bacu.
