5-Bromo-3-nitro-2-pyridinol （CAS # 15862-34-7)
Ibyago n'umutekano
| Kode y'ingaruka | R22 - Byangiza niba byamizwe R37 / 38 - Kurakaza sisitemu yubuhumekero nuruhu. R41 - Ibyago byo kwangirika cyane kumaso R36 / 37/38 - Kurakaza amaso, sisitemu y'ubuhumekero n'uruhu. R20 - Byangiza no guhumeka |
| Ibisobanuro byumutekano | S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushakishe inama mubuvuzi. S36 / 37/39 - Wambare imyenda ikingira, uturindantoki no kurinda amaso / mu maso. S36 - Kwambara imyenda ikingira. |
| Indangamuntu ya Loni | 2811 |
| WGK Ubudage | 3 |
| Kode ya HS | 29337900 |
| Icyitonderwa | Byangiza |
| Icyiciro cya Hazard | IRRITANT |
Ibisobanuro
| Koresha | 5-bromo-2-hydroxy-3-nitropyridine ni intera ngirakamaro ishobora gukoreshwa mugutegura ibice 3-amino-1- (2-oxo-2- (3 '- (trifluoromethyl) - [1,1'-biphenyl ] -4-yl) ethyl) -5- (pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H) -umuntu, iyi nteruro ni DOCK1 ibuza. |
| uburyo bwa synthesis | acide nitric (60-61%, 3.5mL) yongewe kumuti (10mL) ya 5-bromopyridine -2 (1H) -umuntu (1.75g, 10.1mmol) muri acide sulfurike kuri 0 ℃. Uruvange rwemerewe gushyushya ubushyuhe bwicyumba hanyuma rukabyutsa amasaha 3. Uruvangitirane rwa reaction rusukwa mumazi ya barafu kandi imvura yavuyemo ikusanywa no kuyungurura. Ibicuruzwa bivamo byogejwe namazi hanyuma byumishwa mu cyuho, biha 5-bromo-2-hydroxy-3-nitropyridine (960mg, umusaruro wa 43%) nkikomeye cyera. 1H NMR (500MHz, CDCl3) δ: 8.57 (s, 1H), 8.26 (s, 1H). |
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