5-Fluorocytosine （CAS # 2022-85-7)
Ibyago n'umutekano
| Kode y'ingaruka | R40 - Ibimenyetso bike byerekana ingaruka ziterwa na kanseri R36 / 37/38 - Kurakaza amaso, sisitemu y'ubuhumekero n'uruhu. R63 - Ibyago bishobora kugirira nabi umwana utaravuka |
| Ibisobanuro byumutekano | S22 - Ntugahumeke umukungugu. S24 / 25 - Irinde guhura nuruhu n'amaso. S45 - Mugihe habaye impanuka cyangwa niba wumva utameze neza, shaka inama zubuvuzi ako kanya (erekana ikirango igihe cyose bishoboka.) S36 / 37 - Wambare imyenda ikingira hamwe na gants. S36 / 37/39 - Wambare imyenda ikingira, uturindantoki no kurinda amaso / mu maso. S27 - Kuramo ako kanya imyenda yose yanduye. S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushakishe inama mubuvuzi. |
| WGK Ubudage | 2 |
| RTECS | HA6040000 |
| FLUKA BRAND F CODES | 10-23 |
| Kode ya HS | 29335990 |
| Icyitonderwa | Uburozi / Umucyo |
| Icyiciro cya Hazard | IRRITANT, URUMURI |
| Uburozi | LD50 mu mbeba (mg / kg):> 2000 mu kanwa na sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine （CAS # 2022-85-7) Intangiriro
ubuziranenge
Iki gicuruzwa nifu ya kirisiti yera cyangwa idafite umweru, impumuro nziza cyangwa impumuro nke. Gushonga buhoro mumazi, gukomera kwa 1,2% kuri 20 ° C mumazi, gushonga gake muri Ethanol; Ntibishobora gushonga muri chloroform na ether; Gukemura muri acide hydrochloric acide cyangwa sodium hydroxide yumuti. Irahagaze mubushyuhe bwicyumba, igwa kristu mugihe gikonje, naho agace gato gahinduka fluorouracil 5 iyo gishyushye.
Iki gicuruzwa ni imiti igabanya ubukana ikomatanyirizwa mu 1957 kandi ikoreshwa mu buvuzi mu 1969, ikagira ingaruka zigaragara kuri Candida, cryptococcus, amabara y'ibihumyo na Aspergillus, kandi nta ngaruka zibuza izindi fungi.
Ingaruka zayo zo kubuza ibihumyo biterwa no kwinjira mu ngirabuzimafatizo z’ibihumyo byoroshye, aho munsi ya nucleopine deaminase, ikuraho amatsinda yo gukora antimetabolite-5-fluorouracil. Iyanyuma ihindurwamo 5-fluorouracil deoxynucleoside kandi ikabuza synthetase ya thymine nucleoside, ikabuza ihinduka rya uracil deoxynucleoside muri nucleoside ya thymine, kandi ikagira ingaruka kuri synthesis ya ADN.
Koresha
Antifungals. Ikoreshwa cyane cyane kuri kandidiasis ya mucocutaneous, endocarditis kandida, arthritis kandida, meningite ya cryptococcal na chromomycose.
Imikoreshereze na dosiye Umunwa, 4 ~ 6g kumunsi, ugabanijwemo inshuro 4.
umutekano
Umubare w'amaraso ugomba kugenzurwa buri gihe mugihe cyubutegetsi. Abarwayi bafite umwijima nimpyiko badahagije nindwara zamaraso nabagore batwite bagomba gukoresha ubwitonzi; Kwanduza abarwayi bafite ikibazo cyo kubura impyiko.
Igicucu, ububiko bwumuyaga.
