ALPHA-ISO-METHYLIONONE (CAS # 127-51-5)
| Ibimenyetso bya Hazard | Xi - Kurakara |
| Kode y'ingaruka | 43 - Birashobora gutera ubukangurambaga kubwo guhuza uruhu |
| Ibisobanuro byumutekano | S24 / 25 - Irinde guhura nuruhu n'amaso. S36 / 37 - Wambare imyenda ikingira hamwe na gants. |
| Indangamuntu ya Loni | UN1230 - icyiciro cya 3 - PG 2 - Methanol, igisubizo |
| WGK Ubudage | 2 |
| Uburozi | GRAS (FEMA)。 |
Intangiriro
kumenyekanisha
Uruvange rwa methyl na Ethyl isomethyl violet ketone na methyl na ethyl ortho methyl violet ketone.
kamere
Alpha isomethylprednisolone nikintu kama. Nibintu byijimye byijimye. Ku bushyuhe bwicyumba, ifite impumuro idasanzwe.
Alpha isomethylprednisolone ni ketone nziza. Iboneka muri methylation reaction ya alcool ya violet kandi yitwa isomethyl violet ketone. Imiterere ya molekile yayo irimo impeta ya aromatic hamwe nitsinda rya ketone.
Ku bushyuhe bwicyumba, burakomeye, ariko burashobora gushonga mugushyushya. Ntishobora gushonga mumazi, ariko irashobora gushonga mumashanyarazi amwe nka Ethanol na dichloromethane. Yumva urumuri kandi irashobora gukorerwa fotolisi munsi yumuriro wa ultraviolet.
Kubijyanye nimiterere yimiti, α - isomethylprednisolone nuruvange rudasanzwe. Irashobora guhura na reaction nka okiside, kugabanya, kwiyongera, no gusimburwa. Irakora hamwe na reagent ya electrophilique kugirango ikore ibicuruzwa byongeweho. Irashobora kuba protonone imbere ya acide ikomeye. Irashobora kandi guhinduka acide ya ketone ikoresheje okiside.
Uburyo bwo gukora
Ibikurikira nuburyo busanzwe bwo kubyara alpha isomethylprednisolone:
Gutegura ibikoresho byambere: Tegura ibikoresho byambere, harimo Isobutyl ketone na Cyclohexanone. Izi nteruro zombi ningirakamaro zibanziriza synthesis ya α - isomethylprednisolone.
Igenamiterere ryimiterere: Reba isodecanone na cyclohexanol mubihe bikwiye. Ikintu gikunze kugaragara ni ugukora reaction mubihe bya acide, kandi catisale ikoreshwa cyane harimo aside sulfurike (H2SO4) na aside fosifori (H3PO4).
Intambwe zifatika: Vanga urugero runaka rwa isodecanone na cyclohexanol, hanyuma wongeremo catisale ya aside. Noneho, reaction ikorwa mubushyuhe bukwiye, hamwe nubushyuhe bukunze gukoreshwa bwa dogere selisiyusi 50-70. Igihe cyo kubyitwaramo ni amasaha menshi kugeza kumasaha mirongo.
Gutandukana no kwezwa: Nyuma yo kubyitwaramo birangiye, ibicuruzwa bisukurwa bivanze bivanze no kubitandukanya cyangwa ubundi buryo bwo gutandukana.
Crystallisation no gukama: Crystallize kandi yumishe ibicuruzwa bisukuye kugirango ubone ibicuruzwa bya nyuma bya alfa isomethylprednisolone.
