Cbz-L-Glutamic aside 1-benzyl ester （CAS # 3705-42-8)

Intangiriro

Z-Glu-OBzl (Z-Glu-OBzl) ni uruganda kama rusanzwe rukoreshwa nkitsinda ririnda aside amine. Ibikurikira nubusobanuro bwimiterere, imikoreshereze, imyiteguro namakuru yumutekano yikigo:

Kamere:

-Imikorere ya molekulari: C17H17NO4

-Uburemere bwa molekulari: 303.32g / mol

-Ibigaragara: Ifu yera ya kristaline

-Gushonga Ingingo: 84-85 ° C.

-Gukemuka: Gukemura mumashanyarazi kama nka dimethyl sulfoxide na dimethylformamide

- Cbz irinda itsinda irashobora gukurwaho na catalizator ya palladium hydride mugihe cya acide

Koresha:

- Z-Glu-OBzl nitsinda ririnda aside glutamic (Glu), ishobora gukoreshwa muguhuza inkomoko ya aside amine, polypeptide na proteyine.

-Nkitsinda ririnda aside amine mungingo ngengabuzima ngengabuzima, irashobora kurinda itsinda rya amine ya acide glutamic, ikirinda kwanduzwa ningaruka zidasanzwe, kandi ikorohereza kuyikuramo igihe bikenewe.

Uburyo bwo Gutegura:

-Itegurwa rya Z-Glu-OBzl mubisanzwe ririmo inzira nyinshi kandi ririmo urukurikirane rw'imiti. Bumwe mu buryo busanzwe ni ukubanza kurinda itsinda rya carboxyl ya acide glutamic nka t-butoxycarbonyl ester (Boc) hanyuma ukarinda itsinda rya amino nka Cbz. Hanyuma, ibicuruzwa byifuzwa Z-Glu-OBzl bikozwe nigisubizo hamwe na benzyl chloroformate.

Amakuru yumutekano:

- Z-Glu-OBzl igomba gufatwa nkibintu bitera uburakari kandi ukirinda guhura nuruhu n'amaso.

-Iyo ikoreshwa muri laboratoire, hagomba gukurikizwa inzira zumutekano zikwiye, harimo kwambara ibirahure birinda, gants na kote ya laboratoire.

-Guhumeka cyangwa gufata ibimera bigomba kwirindwa kandi hagomba gufatwa ingamba zo gukumira umuriro no guturika mugihe cyo kubika.

-Ikigo kigomba gushyirwa mubidukikije bihumeka neza mugihe cyo gutunganya, kandi imyanda igomba gutabwa neza hakurikijwe amategeko yaho.