Dodec-11-yn-1-ol （CAS # 18202-10-3)

Umutungo wa Shimi:

Inzira ya molekulari	C12H22O
Misa	182.3
Ubucucike	0.8530 (igereranya)
Ingingo yo gushonga	18.8 ° C (igereranya)
Ingingo ya Boling	285.73 ° C (igereranya)
pKa	15.20 ± 0.10 (Byahanuwe)
Imiterere y'Ububiko	2-8 ° C.
Ironderero	1.4535 (igereranya)

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Ibicuruzwa

Dodec-11-yn-1-ol （CAS # 18202-10-3) Amakuru

kwitegura

NaH (7.5g, 60% ikwirakwiza amavuta, 326mmol) yongewemo icyiciro na dodecyl -3-alkyne -1-inzoga (10.0g, 54.95mmol; GF Smith) mubisubizo 0 ℃ byakemuwe na Ethylenediamine (40mL). Nyuma ya 1h, ubushyuhe bwazamutse bugera kuri 70 ℃. Nyuma yandi 8h, shyira imvange ya reaction kuri 0 ° C, urangize witonze ukoresheje amazi akonje (100mL), hanyuma ukuremo ether (3 × 60mL). Igikoresho cya ether cyahujwe cyogejwe namazi (100mL). Gukaraba amazi byakuweho na ether (3 × 60mL). Ibikomoka ku buhinzi-mwimerere byakusanyirijwe hamwe mu cyuho, kandi ibisigara byakorewe chromatografi yinkingi ikoresheje 10% EtOAc / hexane kugirango ibone 11-dodecyne -1-inzoga (7.4g, 74%) yandujwe na 3-5% byabandi isomeri bo mukarere ( regioisomer). TLC: 30% EtOAc / hexane, Rf ≈ 0.4; 1H NMR (300MHz, CDCl3) δ3.66 (t, 2H, J = 7.3Hz), 2.14-2.21 (m, 2H), 1.93 (t, J = 1.9Hz , 1H), 1.20-1.63 (m, 16H).

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