Ethyl 1- (4-mikorerexyphenyl) -6- (4-aminophenyl) -7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo )

Intangiriro

Ibikurikira nintangiriro kumiterere, imikoreshereze, uburyo bwo gutegura namakuru yumutekano ya apixaban hagati 3:

Ubwiza:

Hagati ya Apixaban 3 ni ifumbire mvaruganda. Irakomeye kandi irashonga mumashanyarazi nka ether na Ethyl acetate.

Gukoresha: Bikunze gukoreshwa muburyo bwo kubaga anesthesia no kuvura ububabare bukabije.

Uburyo:

Uburyo bwo gutegura apixaban intermediate 3 burashobora gukorwa nintambwe zikurikira: acide p-nitrobenzoic ikorwa na hypobutylthiourea hamwe na acide acetike na thionyl chloride kugirango ubone N- (p-nitrophenyl) -N- (hypobutylthioylurea) acide formique, hanyuma, yakoresheje reaction ya sodium hydroxide muri sodium oxyde na methanol kugirango ibone apixaban hagati ya 3.

Amakuru yumutekano: Uburyo bukomeye bwo gukora bwumutekano bugomba gukurikizwa mugihe ukoresheje no gutunganya iki kigo. Guhura cyangwa guhumeka neza birashobora guteza ingaruka mbi kubuzima bwabantu. Amakuru yihariye yumutekano agomba gusuzumwa no gutunganywa hakurikijwe amabwiriza n’amabwiriza bijyanye no gukoresha neza no gufata neza. Mugihe cyo gukora ubushakashatsi bwa synthèse chimique, bigomba gukoreshwa mugihe gikwiye cya laboratoire hamwe nibikoresho byokwirinda nka goggles ya chimique, gants zo gukingira, n imyenda ikingira.