FMOC-Arg (Pbf) -OH (CAS # 154445-77-9)
Ibyago n'umutekano
| Ibimenyetso bya Hazard | Xi - Kurakara |
| Kode y'ingaruka | 36/37/38 - Kurakaza amaso, sisitemu yubuhumekero nuruhu. |
| Ibisobanuro byumutekano | S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushakishe inama mubuvuzi. S36 - Kwambara imyenda ikingira. |
| WGK Ubudage | 1 |
| Kode ya HS | 2935 90 90 |
| Icyiciro cya Hazard | IRRITANT |
Intangiriro
Itsinda ririnda FMOC nitsinda rikoreshwa cyane kurinda aminide acide irinda amatsinda yimikorere ya arginine. Ibikurikira nintangiriro kuri bimwe mubintu, imikoreshereze, uburyo bwo gutegura, namakuru yumutekano ya Fmoc-Kurinda Radical:
Ubwiza:
Itsinda ririnda FMOC nitsinda rikurwaho ririnda amine amino. Irashobora kwitwara hamwe nitsinda rya amino muri arginine binyuze muri esterification reaction kugirango ikore ester ya Fmoc-arginine, kugirango igere ku ntego yo kurinda itsinda rya amino. Hariho amatsinda aromatic kuri molekile yitsinda irinda Fmoc ikurura cyane urumuri rwa UV, rutuma ikurwaho ryitsinda ririnda Fmoc rikorwa na irrasiyo ya UV cyangwa uburyo bwa chimique.
Koresha:
Amatsinda arinda FMOC akoreshwa cyane muri synthesis ya peptide hamwe na synthesis ikomeye. Irashobora kurinda neza itsinda rya arginine amino kugirango irinde ingaruka zayo mugihe cya synthesis. Muri synthesis ya peptide, itsinda ririnda Fmoc rirashobora gukurwaho nuburyo bwa alkaline, bigatuma synthesis ya polypeptide ikomeza.
Uburyo:
Itsinda ririnda Fmoc rirashobora gutegurwa nigisubizo cya Fmoc-Cl na arginine. Fmoc-Cl ni reagent ya acide ikomeye ifata hamwe nitsinda rya amino muri arginine kugirango ikore ester ya Fmoc-arginine. Ubusanzwe reaction ikorerwa muri Ethanol mubushyuhe bwicyumba kugeza ubushyuhe bwa barafu.
Amakuru yumutekano:
FMOC-Kurinda Radicals ifite umutekano gukoresha mugihe cya laboratoire isanzwe, ariko ibi bikurikira bigomba kwitonderwa:
- FMOC-CL ni ibintu bitera uburozi kandi bifite uburozi, hagomba kwitonderwa kugirango wirinde guhura nuruhu, guhumeka cyangwa kuribwa. Kora ahantu hafite umwuka mwiza kandi wambare ibikoresho bikingira umuntu.
- FMOC-Kurinda Base ifite umutungo wo kwinjiza cyane imirasire ya ultraviolet, bityo rero hagomba kwitonderwa kugirango wirinde guhura nuruhu n'amaso mugihe cyo kuyikoresha, kandi wirinde amasoko akomeye.
- Kurinda aside hydrolysis ikomeye nka pentafluorophenylcarboxylic aside (TFA) ikoreshwa kenshi mugihe cyo gukuraho amatsinda arinda Fmoc, kandi ni ngombwa kumenya ko imyuka ya TFA ishobora guteza ibyangiritse, bityo rero ni ngombwa gukorera mu iriba- agace gahumeka.
