fmoc-O-tert-butyl-D-tyrosine (CAS # 118488-18-9)

Fmoc-O-tert-butyl-D-tyrosine ni aside ikoreshwa cyane ikingira aside amine. Ibikurikira nubusobanuro bwimiterere yabyo, imikoreshereze, imiterere namakuru yumutekano:

Kamere:
Fmoc-O-tert-butyl-D-tyrosine ni kirisiti yera ikomeye. Nibintu kama hamwe nubumara bwa C30H31NO7 nuburemere bwa molekile ya 521.57g / mol. Uruvange ni inkomoko ya tyrosine aho itsinda rya amino ryitwa Fmoc (9-fluorofluorenylformyl) irinda itsinda kandi itsinda rya acide karubike ryitwa O-tert-butyl.

Koresha:
Fmoc-O-tert-butyl-D-tyrosine ikunze gukoreshwa nka aside amine ikingiwe muri synthesis ya peptide. Muguhuza itsinda ririnda Fmoc mumatsinda ya amino, reaction zidakenewe zirashobora gukumirwa mugihe cya synthesis. Ikoreshwa cyane muri synthesis ikomeye kandi irashobora gukoreshwa muguhuza polypeptide na proteyine.

Uburyo bwo Gutegura:
Gutegura Fmoc-O-tert-butyl-D-tyrosine muri rusange bikorwa na synthesis. Ubwa mbere, tyrosine ikorwa na Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) kugirango itange Fmoc-O-tyrosine. Cesium tert-butyl bromide noneho yongewe kubitekerezo kugirango isuzume itsinda rya acide karubike kugirango ibe Fmoc-O-tert-butyl-D-tyrosine. Hanyuma, ibicuruzwa bisukuye biboneka ku ntambwe zo gutegera, gukaraba no gukama.

Amakuru yumutekano:
Fmoc-O-tert-butyl-D-tyrosine ni uruganda ruhamye mubihe bisanzwe kandi ntiruhindagurika rugaragara mubushyuhe bwicyumba. Mugihe cyo kuyikoresha, birakenewe kubahiriza inzira zumutekano wa laboratoire, kwambara ibikoresho bikingira, no kwirinda guhura nuruhu n'amaso. Mugihe cyo gutunganya cyangwa kubika, bigomba kubikwa ahantu humye, hakonje kandi kure yumuriro na okiside. Muri icyo gihe, guhura na okiside ikomeye na acide zikomeye bigomba kwirindwa kugirango wirinde ingaruka mbi. Shakisha ubuvuzi bwihuse niba kuribwa cyangwa guhura nimpanuka.