fmoc-L-4-hydroxyproline （CAS # 88050-17-3)

Intangiriro

Fmoc-L-hydroxyproline (Fmoc-Hyp-OH) ni aside amine ikomoka kumitungo ikurikira kandi ikoresha:

Ubwiza:

- Kugaragara: Ifu yera cyangwa yera-ifu ya kristaline

- Gukemura: Gukemura mumashanyarazi nka DMF, DMSO na methanol

- agaciro ka pKa: 2.7

Koresha:

- Fmoc-Hyp-OH ikoreshwa cyane cyane muri peptide synthesis na peptide synthesis muri synthesis ikomeye

- Ikora nk'itsinda ririnda kurinda amatsinda y'uruhererekane rw'amatsinda ya acide ya amino mugihe cyo guhuza ibice bikomeye kugirango birinde ingaruka zitunguranye kandi bikomeze guhitamo

Uburyo:

Fmoc-Hyp-OH irashobora gutegurwa mugukora aside Fmoc-amino hamwe na L-hydroxyproline mumashanyarazi akwiye. Imiterere yimyitwarire isanzwe ikubiyemo ubushyuhe bukwiye hamwe na catalizator ikwiye, nka N, N-dimethylpyrrolidone (DMAP). Ibicuruzwa bivamo bisukurwa nintambwe nkimvura, gukaraba, no gukama.

Amakuru yumutekano:

- FMOC-HYP-OH ni uruganda kama kandi rugomba gukemurwa hakurikijwe protocole yumutekano wa laboratoire.

- Umukungugu urashobora guhumeka hanyuma ugahura nuruhu, bityo rero ugomba kwitonda kugirango wirinde guhumeka neza cyangwa guhura.

- Mugihe gikwiye, ibikoresho bikwiye byo kurinda umuntu nka laboratoire ya laboratoire, kurinda amaso, imyenda ikingira, nibindi bigomba kwambara.

- Igomba kubikwa neza ifunze ahantu humye, hakonje, kure yumuriro nibintu byaka.