Fmoc-L-glutamic aside-gamma-benzyl ester (CAS # 123639-61-2)

Fluorene mikorerexycarbonyl-L-glutamic aside-Γ-benzyl ni uruganda kama rukoreshwa muri synthesis ya peptide muri synthesis ikomeye. Kamere yacyo:
- Kugaragara: Umweru kugeza umuhondo wijimye
- Gukemura: Fmoc-L-Glu (OtBu) -OH ifite ibisubizo byiza mumashanyarazi asanzwe.

Ikoreshwa nyamukuru rya Fmoc-L-Glu (OtBu) -OH ni nkitsinda ririnda peptide. Iyo ushushanya iminyururu ya peptide, Fmoc-L-Glu (OtBu) -OH ihuza aside amine, ikarinda ibikorwa byabo kwirinda reaction zidasanzwe hamwe nizindi reaction. Nyuma yuko reaction irangiye, Fmoc-L-Glu (OtBu) -OH irashobora gukurwaho ukuraho itsinda ririnda kugarura ibikorwa bya acide amine.

Gutegura Fmoc-L-Glu (OtBu) -OH biragoye kandi mubisanzwe bisaba gukoresha urukurikirane rwintambwe ngengabihe. Acide Glutamic ikorwa na bromoacetate kugirango ibone Ethyl glutamate. Noneho, Ethyl glutamate isubizwa hamwe na alcool ya benzyl kugirango ikore Ethyl glutamate benzyl inzoga ester. Ethyl glutamate benzyl inzoga ester yakiriwe na Fmoc-Cl kugirango itange umusaruro ugenewe Fmoc-L-Glu (OtBu) -OH.

Amakuru yumutekano: Fmoc-L-Glu (OtBu) -OH numuti wa laboratoire kandi ugomba gukoreshwa mugikorwa cya laboratoire itekanye. Kurikiza imyitozo rusange yumutekano muri laboratoire, harimo kwambara ibikoresho birinda umuntu (urugero, gants ya laboratoire, indorerwamo, nibindi), wirinde guhura nuruhu no guhumeka, no gukorera muri laboratoire ihumeka neza. Uru ruganda rugomba kubikwa mu kintu cyumuyaga, kure y’umuriro na okiside.