L-Pyroglutamic aside CAS 98-79-3
Ibyago n'umutekano
| Ibimenyetso bya Hazard | Xi - Kurakara |
| Kode y'ingaruka | 36/37/38 - Kurakaza amaso, sisitemu yubuhumekero nuruhu. |
| Ibisobanuro byumutekano | S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushakishe inama mubuvuzi. S36 - Kwambara imyenda ikingira. S37 / 39 - Kwambara uturindantoki dukwiye no kurinda amaso / kurinda amaso |
| WGK Ubudage | 3 |
| RTECS | TW3710000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Yego |
| Kode ya HS | 29337900 |
| Intangiriro | aside pyroglutamic ni 5-oxyproline. Ikorwa no kubura umwuma hagati yitsinda α-NH2 na γ-hydroxyl groupe ya acide glutamic kugirango ibe umusemburo wa lactam; Irashobora kandi gushingwa mugutakaza itsinda rya Amido muri molekile ya glutamine. Niba glutathione synthetase ibuze, irashobora gutera pyroglutamemia, urukurikirane rwibimenyetso byubuvuzi. Pyroglutamemia ni indwara ya metabolisme ya aside iterwa no kubura glutathione synthetase. Kugaragara kwa Clinical kuvuka amasaha 12 ~ 24 yo gutangira, hemolysis igenda itera imbere, jaundice, Acidose ya Metabolic idakira, indwara zo mumutwe, nibindi.; Inkari zirimo aside pyroglutamic, aside ya lactique, Alpha deoxy4 lipide aside glycoloacetic. Kuvura, ibimenyetso, witondere guhindura imirire nyuma yimyaka. |
| imitungo | L-pyroglutamic aside, izwi kandi nka L-pyroglutamic aside, L-pyroglutamic. Uhereye kuri Ethanol na peteroli ivangwa na ether mu mvura yimvura ya orthorhombic idafite cone Crystal, gushonga ya 162 ~ 163 ℃. Gushonga mumazi, inzoga, acetone na acide acike, Ethyl acetate-soluble, idashonga muri ether. Guhinduranya optique yihariye -11.9 ° (c = 2, H2O). |
| Ibiranga n'imikoreshereze | muruhu rwumuntu rurimo imikorere yubushuhe bwibintu byokunywa amazi-ibintu bisanzwe bitanga amazi, ibiyigize ni aside amine hafi (irimo 40%), aside pyroglutamic (irimo 12%), imyunyu ngugu (Na, K, Ca, Mg, nibindi). irimo 18.5%), hamwe nibindi binyabuzima (birimo 29.5%). Kubera iyo mpamvu, aside pyroglutamic ni kimwe mu bintu by'ingenzi bigize uruhu rusanzwe rwo mu ruhu, kandi ubushobozi bwarwo bwo gutanga amazi burenze kure ubwa glycerol na propylene glycol. Kandi idafite uburozi, nta gukangura, ni Kwita ku ruhu rugezweho, kwisiga umusatsi kwisiga ibikoresho byiza cyane. Acide Pyroglutamic nayo igira ingaruka mbi kubikorwa bya okiside ya tirozine, bityo ikarinda kwinjiza ibintu bya "melanoid" muruhu, bigira ingaruka yera kuruhu. Ifite ingaruka yoroshye kuruhu, irashobora gukoreshwa mumavuta yo kwisiga. Usibye gukoreshwa mubintu byo kwisiga, aside L-pyroglutamic irashobora kandi kubyara ibikomoka hamwe nibindi bintu kama kama, bigira ingaruka zidasanzwe kubikorwa byo hejuru, bigira ingaruka nziza kandi nziza, nibindi. Imiti igabanya ubukana bwa amine; Abahuza kama. |
| uburyo bwo gutegura | Acide L-pyroglutamic ikorwa mugukuraho umunota umwe wamazi muri molekile ya acide L-glutamic, kandi inzira yayo yo kuyitegura iroroshye, intambwe zingenzi ni ukugenzura ubushyuhe nigihe cyo kuvomera. . reaction. Umuti udafite umwuma wari Tan. . Nyuma yo gukonja kugeza kuri 40 kugeza kuri 50 ° C., karubone ikwiye ya karubone ikora kugirango yongere amabara (isubirwamo kabiri). Igisubizo kitagira ibara kiboneye cyabonetse. . no mumazi ashyushye yo kwiyuhagira kugirango atinde kristu, nyuma yamasaha 10 kugeza kuri 20 nyuma yo gutegura kristu itagira ibara. Ingano ya L-pyroglutamic aside yo kwisiga biterwa no kuyikora. Iki gicuruzwa nacyo gishobora gukoreshwa kumavuta yo kwisiga muburyo bwa 50% byibanze. |
| acide glutamic | acide glutamic ni aside amine igizwe na poroteyine, ifite urunigi rwa aside irike, kandi ikerekana hydrotropism. Acide Glutamic irashobora kwanduzwa na aside ya pyrrolidone ya karubasi ya aside, I .e., Acide pyroglutamic. aside glutamic iri hejuru cyane muri poroteyine zose zintete, itanga alpha-ketoglutarate ikoresheje aside ya tricarboxylic. Alpha ketoglutaric aside irashobora guhuzwa neza na ammonia munsi ya catalizike ya glutamate dehydrogenase na NADPH (coenzyme II), kandi irashobora kandi guterwa na aminotransferase ya aspartate cyangwa alanine aminotransferase, aside glutamic ikorwa no kwanduza aside aside cyangwa alineine; Byongeye kandi, aside glutamic irashobora guhindurwa muburyo bwa protine na ornithine (biva kuri arginine). Glutamate rero ni intungamubiri zidakenewe aside aside amine. Iyo aside glutamic yandujwe munsi ya catalizike ya glutamate dehydrogenase na NAD (coenzyme I) cyangwa ikimurwa ikava mumatsinda ya amino munsi ya catalizike ya aspartate aminotransferase cyangwa alanine aminotransferase kugirango ikore alpha ketoglutarate, yinjira mubisukari bya tricarboxylic. inzira ya gluconeogenic, aside glutamic rero ni aside ya glycogeneque ikomeye. aside glutamic mubice bitandukanye (nk'imitsi, umwijima, ubwonko, nibindi) irashobora guhuza glutamine na NH3 binyuze muri catalizike ya glutamine synthetase, nigicuruzwa cyangiza ammonia, cyane cyane mubice byubwonko, ndetse nuburyo bwo kubika no gukoresha ammonia mu mubiri (reba “glutamine na metabolism yayo”). acide glutamic ikomatanyirizwa hamwe na acetyl-CoA nka cofactor ya mitochondrial carbamoyl phosphate synthase (igira uruhare muri synthesis ya urea) binyuze muri catalizike ya acetyl-glutamate. acid-aminobutyric aside (GABA) nigicuruzwa cya decarboxylation ya acide glutamic, cyane cyane mukwibanda cyane mumyanya yubwonko, kandi ikanagaragara mumaraso, imikorere yayo ya physiologique ifatwa nkibibuza neurotransmitter, antispasmodic na hypnotic ingaruka ziterwa na the kwinjiza ivuriro rya echinocandin birashobora kugerwaho binyuze muri GABA. Catabolism ya GABA yinjira muri acide ya tricarboxylic ihindura GABA transaminase na aldehyde dehydrogenase muri acide succinic kugirango ibe shunt ya GABA. |
| Koresha | ikoreshwa nkumuhuza muri synthesis organique, inyongeramusaruro, nibindi. ikoreshwa mu biribwa, ubuvuzi, kwisiga no mu zindi nganda |
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