Methyl 2-cyanoisonicotine （CAS # 94413-64-6)
Ibyago n'umutekano
| Icyiciro cya Hazard | 6.1 |
Uburyo bwo gukora
intego yagenewe yateguwe na okiside, amidation hamwe na dehidrasi hamwe na methyl 2-methyl 4-pyridinecarboxylate (2) nkibikoresho byo gutangira. imiterere yacyo yemejwe na 1H NMR na MS, kandi umusaruro wose wari 53.0%. Ingaruka zo kugaburira kugaburira, ubushyuhe bwa kristu, igihe cyo kubyitwaramo nibindi bintu kubicuruzwa byakozwe nubushakashatsi bwibintu bimwe, kandi ibintu byakozwe byari byiza: n (2): n (potassium permanganate) = 1.0: 2.5, ubushyuhe bwa kristu 0 ~ 5 ℃; n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0: 1.4, reaction; reaction ya dehydrasiyo ihitamo trifluoroacetic anhydride-triethylamine sisitemu nkibikoresho byo kubura amazi. Inzira iroroshye gukora, ibintu byitwara biroroshye, byoroshye kuzamura umusaruro, kandi bifite agaciro keza mubikorwa.
Koresha
Tobisostat ikoreshwa mu kuvura hyperuricemia idakira ya gout. Ugereranije nibiyobyabwenge gakondo allopurinol (analine ya purine), ntabwo bizagira ingaruka kuri metabolisme ya purine na pyridine hamwe na enzyme, kandi bigabanya aside irike Ingaruka irakomeye, nta buyobozi bunini busubirwamo busabwa, kandi umutekano ni mwiza. Methyl 2-cyano-4-pyridine carboxylate ni ibikoresho byingenzi byingirakamaro kuri synthesis ya Tobiso.
