Mitotan （CAS # 53-19-0)

Umutungo wa Shimi:

Inzira ya molekulari	C14H10Cl4
Misa	320.04
Ubucucike	1.3118 (igereranya)
Ingingo yo gushonga	77-78 ° C (lit.)
Ingingo ya Boling	405.59 ° C (igereranya)
Amazi meza	<0.1 g / 100 mL kuri 24 ºC
Gukemura	DMSO: gushonga20mg / mL, birasobanutse
Kugaragara	ifu
Ibara	cyera to beige
Merk	13,6237 / 13,6237
BRN	2056007
Imiterere y'Ububiko	Ikirere cyimbere, Ubushyuhe bwicyumba
Ironderero	1.6000 (ikigereranyo)
Ibintu bifatika na shimi	Gushonga ingingo 76-78 ° C. gushonga amazi <0.1g / 100 mL kuri 24 ° C.
Koresha	Ibicuruzwa bigenewe ubushakashatsi bwa siyansi gusa kandi ntibizakoreshwa mubindi bikorwa.
Mu bushakashatsi bwa vitro	Imbeba TalphaT1 umurongo wimikorere, Mitotane ibuza imvugo nogusohora kwa TSH, ikabuza igisubizo cya TSH kuri TRH, kandi igabanya ubuzima bwimikorere, kandi itera apoptose. Muri pitoitar TSH-isohora imbeba ya selile, Mitotane ntabwo ibangamira imisemburo ya tiroyide, ahubwo igabanya ibikorwa byibanga nubuzima bwa selile. Mitotane itera adrenal cortical necrosis, kwangirika kwa mitochondrial membrane, no guhuza bidasubirwaho na poroteyine CYP. Mitotane (10-40 μ m) yabujije ururenda rwa cortisol ya basal na cAMP ariko ntirwateje urupfu. Mitotane yerekanye ingaruka zo kubuza proteine yibanze na P450scc. Mitotane (40 μ m) yagabanije cyane urwego rwa mRNA rwa StAR, CYP11A1 na cyp21. Mitotane (40 μ m) hafi ya yose yatesheje agaciro kwinjiza STAR, CYP11A1, CYP17, na CYP21 mRNA na adenosine 8-bromo-cyclic fosifate. Mu cyiciro cya S cya selile H295R, guhuza Mitotane na gemcitabine byerekanaga antagonism kandi bikabangamira gemcitabine-yunganirwa no guhagarika ingirabuzimafatizo.
Mu bushakashatsi bwa vivo	Imbeba, Mitotane (60 mg / kg) yagabanije cyane mitochondrial adrenal na microsomal “P-450 ″ na poroteyine za microsomal 34%, 55% na 35%.

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Ibicuruzwa birambuye

Ibicuruzwa

Ibimenyetso bya Hazard	Xn - Byangiza
Kode y'ingaruka	40 - Ibimenyetso bike byerekana ingaruka ziterwa na kanseri
Ibisobanuro byumutekano	36/37 - Wambare imyenda ikingira hamwe na gants.
Indangamuntu ya Loni	3249
WGK Ubudage	3
RTECS	KH7880000
Kode ya HS	2903990002
Icyiciro cya Hazard	6.1 (b)
Itsinda ryo gupakira	III

Intangiriro

Mitotane ni ifumbire mvaruganda ifite izina ryimiti N, N'-methylene diphenylamine. Ibikurikira nintangiriro kumiterere, imikoreshereze, uburyo bwo gutegura namakuru yumutekano ya mitotane:

Ubwiza:

- Mitotane ni kirisiti itagira ibara ikomeye ikemuka mumashanyarazi nka Ethanol, ether, na chloroform.

- Mitotane ifite impumuro ikomeye.

Koresha:

- Mitotane ikoreshwa cyane cyane muguhuza reaction muri synthesis organique kandi ikoreshwa kenshi nka reagent na catalizator.

- Irashobora kugira uruhare muburyo butandukanye bwimiti, nko guhuza alkine, alkylation yibintu bya aromatic, nibindi.

Uburyo:

- Mitotane irashobora guhuzwa nintambwe ebyiri. Formaldehyde ikoreshwa na diphenylamine mugihe cya alkaline kugirango ikore N-formaldehyde diphenylamine. Hanyuma, na pyrolysis cyangwa igenzurwa na okiside igenzurwa, ihinduka mitotane.

Amakuru yumutekano:

- Mitotane ni uruganda rurakaza kandi ntirukwiye guhura nuruhu n'amaso. Ibikoresho bikwiye byo kurinda nka gants, indorerwamo, imyenda yo gukingira bigomba kwambara mugihe ukora.

- Mugihe ubitse kandi ubitunganya, witondere gufunga no kurinda urumuri kugirango wirinde guhura numwuka nubushuhe.

- Mitotane ibora ku bushyuhe bwinshi kugirango itange imyuka yubumara, irinde gushyuha cyangwa guhura nibindi bintu byaka.

- Reba amabwiriza yaho kandi ukurikize uburyo bukoreshwa mubikorwa byumutekano mugihe ubijugunye.

Mbere: 4- (4-mikorerexyphenyl) -1-butanol （CAS # 52244-70-9)

Ibikurikira: 2-Chloro-5-aminopyridine （CAS # 5350-93-6)

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