N (alpha) -fmoc-N (epsilon) - (2-chloro-Z) -L-lysine (CAS # 133970-31-7)

Fmoc- (2-chlorobenzyloxycarbonyl) lysine ni inkomoko ya aside amine ikunze gukoreshwa ifite ibintu bikurikira: 1. Kugaragara: ifu yera ya kristaline;
2. Inzira ya molekile: C26H24ClNO5;
3. Uburemere bwa molekuline: 459.92g / mol;
4. Gukemura: Gukemuka mumashanyarazi kama nka dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dichloromethane, nibindi, bidashonga mumazi;
5. Itsinda ryayo rya carboxyl irashobora gukora kugirango ikore ester, hanyuma ikore reaction ya hamwe na aside amine isigaranye kugirango ihuze urunigi rwa polypeptide. Itsinda rya Fmoc rirashobora gukurwaho byoroshye nyuma yimyitozo irangiye kugirango yerekane amine arinzwe.

Uburyo bwo gutegura Fmoc- (2-chlorobenzyloxycarbonyl) lysine muri rusange harimo intambwe zikurikira:

1. Kwakira lysine hamwe na N-hydroxybutyrimide (Pbf) kugirango utangire itsinda ririnda;
2. Kwakira lysine-Pbf ikomoka kuri alcool 2-chlorobenzyl kugirango ikore lysine ya Fmoc- (2-chlorobenzyloxycarbonyl);
3. Ibicuruzwa bivanwa hamwe na solve ikwiye kandi bigasukurwa na kristu kugirango ubone ibicuruzwa byiza.

Kubyerekeranye namakuru yumutekano, lymine ya Fmoc- (2-chlorobenzyloxycarbonyl) ni reagent yimiti kandi hagomba gufatwa ingamba zikwiye zumutekano. Ibikoresho bikwiye byo kurinda, nk'uturindantoki twa laboratoire, ibirahure, n'imyenda ya laboratoire, bigomba kwambarwa mugihe cy'igerageza. Irinde guhumeka ifu cyangwa ibisubizo, irinde guhura nuruhu n'amaso. Mugihe uhuye nimpanuka, kwoza ako kanya n'amazi menshi hanyuma ushake ubuvuzi. Menya neza ko ikoreshwa muri laboratoire itekanye kandi ikabikwa neza kugirango wirinde impanuka.