N-Cbz-D-Tryptophan （CAS # 2279-15-4)

Intangiriro

N (^ a) -Benzyloxycarbonyl-D-tryptophan (N (^ a) -Benzyloxycarbonyl-D-tryptophan) ni imiti, izwi kandi nka CBZ-D-Trp. Ibikurikira nubusobanuro bwimiterere yabyo, imikoreshereze, imiterere namakuru yumutekano:

Kamere:

N (^ a) -Benzyloxycarbonyl-D-tryptophan ni cyera kugeza umuhondo kristaline ikomeye. Irahagaze neza mubushyuhe bwicyumba kandi irashobora kubikwa igihe kirekire mubihe bidasanzwe. Ntishobora gushonga mumazi, ariko irashonga mumashanyarazi amwe nka methanol na dimethyl sulfoxide.

Koresha:

N (^ a) -Benzyloxycarbonyl-D-tryptophan ikoreshwa kenshi nko kurinda amatsinda muri synthesis organique, cyane cyane muri synthesis ya peptide. Ikoreshwa ryayo nyamukuru ni nkibikomoka kuri acide ya amino kugirango ikomatanye module yihariye muri polypeptide cyangwa urunigi rwa poroteyine. Irashobora kugira uruhare runini muguhuza imiti mishya murubu buryo.

Uburyo:

Gutegura N (^ a) -Benzyloxycarbonyl-D-tryptophan mubusanzwe bikorwa na synthesis. Ubwa mbere, inzoga ya benzyl na dioxyde de carbone irakorwa kugirango ikore aside benzyloxycarboxylic, hanyuma aside amine tryptophan na acide benzyloxycarboxylic ihabwa agaciro kugirango ibone ibicuruzwa bya CBZ-D-Trp. Igisubizo gisaba ubufasha bwa catalizike zimwe na zimwe.

Amakuru yumutekano:

N (^ a) -Benzyloxycarbonyl-D-tryptophan ifite amakuru yumutekano muke, ariko ukurikije amakuru ahari, mubisanzwe bifatwa nkuburozi. Kumara igihe kirekire cyangwa guhura cyane birashobora kugira ingaruka mbi kubuzima. Kubwibyo, ingamba zikwiye zumutekano zigomba gufatwa mugihe ukoresheje, kubika no gutunganya iki kigo, harimo kwambara ibikoresho byabashinzwe kurinda no gufata neza ahantu hafite umwuka mwiza. Mugihe kimwe, birakenewe gukurikiza inzira zumutekano zikoreshwa hamwe nuburyo bwo kujugunya.

Nyamuneka menya ko iyi ngingo ari incamake yikigo kivugwa, kandi ikoreshwa ryihariye hamwe nisuzuma ryibyago bigomba gukorwa mubidukikije bya laboratoire. Mbere yo gukoresha ibintu byose bya shimi, nyamuneka urebe neza ko wiga amakuru arambuye kandi ubaze umunyamwuga mbere.