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N-Cbz-L-Threonine （CAS # 19728-63-3) Ishusho Yerekanwe
  • N-Cbz-L-Threonine （CAS # 19728-63-3) 1

N-Cbz-L-Threonine （CAS # 19728-63-3)

Umutungo wa Shimi:

Inzira ya molekulari C12H15NO5
Misa 253.25
Ubucucike 1.2499 (igereranya)
Ingingo yo gushonga 101-103 ° C (lit.)
Ingingo ya Boling 396.45 ° C (igereranya)
Guhinduranya byihariye (α) -4.7 º (c = 4, aside aside)
Flash point 261.3 ° C.
Gukemura hafi gukorera mu mucyo muri Methanol
Umwuka 3.7E-11mmHg kuri 25 ° C.
Kugaragara Ifu yera kugeza yoroheje umuhondo wa kirisiti
Ibara Umweru Kuri Hafi Yera
BRN 2335409
pKa 3.58 ± 0.10 (Biteganijwe)
Imiterere y'Ububiko Ikidodo cyumye, Ubike muri firigo, munsi ya -20 ° C.
Ironderero -4.9 ° (C = 2, AcOH)
MDL MFCD00065948
Koresha Byakoreshejwe kuri biohimiki reagent, peptide synthesis.

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Ibyago n'umutekano

Ibimenyetso bya Hazard Xn - Byangiza
Kode y'ingaruka R20 / 21/22 - Byangiza muguhumeka, guhura nuruhu kandi niba byamizwe.
R36 / 37/38 - Kurakaza amaso, sisitemu y'ubuhumekero n'uruhu.
Ibisobanuro byumutekano S22 - Ntugahumeke umukungugu.
S24 / 25 - Irinde guhura nuruhu n'amaso.
S36 - Kwambara imyenda ikingira.
S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushakishe inama mubuvuzi.
WGK Ubudage 3
Kode ya HS 29242990

 

 

N-Cbz-L-Threonine （CAS # 19728-63-3) Amakuru

kwitegura ongeramo 50mL ya L-Thr (30mmol) hanyuma ukonje ya Na2CO3 ikonje mumacupa ya 250mL, hanyuma ukangure ushonga mubwogero bwa barafu. Tera 20mL ya Z-OSu (39.4mmol) umuti wa acetone mumacupa ya reaction; Kangura reaction kuri 25 ℃, TLC-UV fluorescence hamwe nuburyo bwa amabara ya ninhydrin ikurikirana inzira. Nyuma yo kubyitwaramo, ongeramo H2O20mL, gukuramo na Et2O (30mL × 2) kuri pH> 9, gukusanya icyiciro cyamazi, hindura pH kuri 3 ~ 4 hamwe na 1.5NHCl, gukuramo na EtOAc (30mL × 3), komatanya icyiciro kama, oza hamwe n'umuti wuzuye wa NaCl (25mL × 2), wumishe hamwe na Anhydrous Na2SO4, reba ubuziranenge na TLC-ultraviolet fluorescence hamwe nuburyo bwo guteza imbere ibara rya ninhydrin, hanyuma bigahumuka munsi yumuvuduko ukabije, kumisha vacuum kugirango ubone amazi yumuhondo wumuhondo N-benzyloxycarbonyl-L-threonine, ibikwa mubushyuhe buke.
Koresha CBZ-L-threonine nuburyo bwa N-Cbz burinzwe bwa L-threonine (T405500). L-threonine ni aside amine yingenzi kandi ikoreshwa muburyo bwo kugaburira no kongera ibiryo. Imiterere ya mutant ya Escherichia coli yabyaye L-threonine nyinshi mubushakashatsi no kugaburira ibiryo. L-threonine isanzwe iboneka mu mafi n’inkoko kandi ikinjizwa muri poroteyine zimwe na zimwe z’umubiri, nka hemoglobine na insuline.
Byakoreshejwe kuri biohimiki reagent na peptide synthesis.

 

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