Isoko ry’imiti y’ibihugu by’i Burayi ririmo guhinduka cyane, bitewe n’ubushake bugenda bukenerwa mu kuvura udushya no gukomeza iterambere ry’ibikorwa byo gukora ibiyobyabwenge. Umwe mu bakinnyi bakomeye muri uru rwego ni 2-aminobenzonitrile, imiti ikomeye y’imiti yakunze kwitabwaho cyane kubera uruhare rwayo muri synthesis ya lapatinib, imiti igamije gukoreshwa cyane cyane mu kuvura kanseri y'ibere.
2-Aminobenzonitrile, ibiranga imiti1885-29-6, ni impumuro nziza ni urufunguzo rwubaka mu gukora imiti itandukanye. Imiterere yihariye ya chimique ituma iba intera yingenzi muguhuza lapatinib, inzitizi ebyiri ya tyrosine kinase inhibitor yibasira reseptor yibintu byiyongera (EGFR) hamwe na reseptor 2 (HER2). Ubu buryo bwibikorwa ni ingirakamaro cyane cyane kubarwayi barwaye kanseri yamabere ya HER2, itanga uburyo bwo kuvura bugabanya kugabanya kwangirika kwingirabuzimafatizo ugereranije na chimiotherapie gakondo.
Mu myaka yashize, icyifuzo cya lapatinib cyiyongereyeho ubwiyongere bwa kanseri y'ibere ndetse no kurushaho kumenya akamaro k'ubuvuzi bwihariye. Kubera iyo mpamvu, isoko ryabunzi ba farumasi, harimo 2-aminobenzonitrile, ryaguka vuba. Uruganda rukora imiti y’ibihugu by’i Burayi rushora imari cyane mu bushakashatsi n’iterambere kugira ngo rutezimbere umusaruro wa lapatinib, ari nacyo gitera icyifuzo cy’abahuza bo mu rwego rwo hejuru.
Kimwe mu bintu by'ingenzi bigira ingaruka ku isoko ry’iburayi 2-aminobenzonitrile ni akarere gakomeye ko kugenzura ibidukikije. Ikigo cy’ubuvuzi bw’ibihugu by’i Burayi (EMA) cyashyizeho umurongo ngenderwaho uhamye wo gukora no kugenzura ubuziranenge bw’imiti y’imiti, kugira ngo hubahirizwe gusa amahame yo mu rwego rwo hejuru. Uru rwego rwo kugenzura ntirurinda umutekano w’abarwayi gusa ahubwo runateza imbere udushya mu nganda mu gihe ibigo bihatira kubahiriza aya mahame mu gihe biteza imbere uburyo bushya kandi bunoze.
Byongeye kandi, isoko ryiburayi rirangwa no kwiyongera kuramba hamwe na chimie yicyatsi. Abakora imiti barashaka uburyo bwangiza ibidukikije kugirango batange abahuza nka 2-aminobenzonitrile. Ihinduka riterwa nigitutu cyamabwiriza hamwe nibisabwa nabaguzi kubikorwa birambye. Amasosiyete arimo gushakisha inzira zindi zo guhuza imyanda no kugabanya ingaruka z’ibidukikije ku bikorwa byayo, bijyanye n’intego nini z’ibihugu by’Uburayi.
Usibye kuramba, isoko ryimiti yuburayi nayo irimo guhura niterambere ryikoranabuhanga. Kwinjiza ubwenge bwubuhanga (AI) no kwiga imashini mugikorwa cyo guteza imbere ibiyobyabwenge birahindura uburyo abahuza imiti bakora. Izi tekinoroji zituma ibigo byorohereza inzira zogukora, kugabanya ibiciro byumusaruro, no kwihutisha igihe cyo gucuruza imiti yingenzi nka lapatinib.
Mugihe isoko ryimiti yuburayi ikomeje gutera imbere, uruhare rwabunzi nka 2-aminobenzonitrile ruzakomeza kuba ingirakamaro. Gukomeza ubushakashatsi mubikorwa bishya hamwe nuburyo bwa syntetique birashoboka ko bizatera imbere guhanga udushya mu musaruro wa lapatinib hamwe nubundi buryo bwo kuvura. Ibi na byo bizamura uburyo bwo kuvura abarwayi kandi bigire uruhare mu kuzamuka muri rusange mu nganda z’imiti i Burayi.
Muri make, ihuriro ryo kubahiriza amabwiriza, kuramba, no guhanga udushya mu ikoranabuhanga ririmo gutegura ejo hazaza h’isoko ry’imiti y’iburayi. Mu gihe icyifuzo cya lapatinib n’abunzi bayo, nka 2-aminobenzonitrile, gikomeje kwiyongera, abafatanyabikorwa hirya no hino mu nganda bagomba guhuza n’izi nzira kugira ngo bakomeze guhatana kandi bahuze ibyifuzo by’abarwayi. Ejo hazaza h’abahuza imiti harasa, kandi 2-aminobenzonitrile iri ku isonga ryiki kibanza gifite imbaraga.
Igihe cyo kohereza: Ukuboza-12-2024