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Nicorandil （CAS # 65141-46-0) Ishusho Yerekanwe
  • Nikorandil （CAS # 65141-46-0) 1

Nicorandil （CAS # 65141-46-0)

Umutungo wa Shimi:

Inzira ya molekulari C8H9N3O4
Misa 211.17
Ubucucike 1.4271 (igereranya)
Ingingo yo gushonga 92 ° C.
Ingingo ya Boling 350.85 ° C (igereranya)
Flash point 230 ° C.
Gukemura DMSO:> 10 mg / mL. Gushonga muri methanol, Ethanol, acetone cyangwa acide glacial acetike, gushonga gake muri chloroform cyangwa mumazi, hafi yo kudashonga muri ether cyangwa benzene.
Umwuka 1.58E-08mmHg kuri 25 ° C.
Kugaragara Ifu yera kugeza yera isa nifu ya kristaline
Ibara cyera kugeza cyera
Merk 14,6521
Imiterere y'Ububiko 2-8 ° C.
Ironderero 1.7400 (igereranya)
MDL MFCD00186520
Ibintu bifatika na shimi Ifu yera ya kristaline, impumuro nziza cyangwa impumuro nkeya, irakaze. Gushonga muri methanol, Ethanol, acetone cyangwa acide acike, gushonga gake muri chloroform cyangwa mumazi, bike ntibishonga muri ether cyangwa benzene. Gushonga ingingo 88.5-93.5 ° c. Uburozi bukabije LD50 imbeba (mg / kg): 1200-1300 umunwa, 800-1000.
Koresha Mu rwego rwo gukumira indwara z'umutima zifata umutima, angina pectoris
Mu bushakashatsi bwa vitro Nikorandil (100 mM) yongereye okiside ya flavoprotein, ariko ntiyagize ingaruka ku miyoboro ya membrane, igarura imiyoboro ya mitoK (ATP) hamwe na surfaceK (ATP) yibitekerezo byikubye inshuro 10. Nicorandil igabanya urupfu rw'uturemangingo mu buryo bwa ischemic granulation model, ingaruka z'umutima zifata umutima uhagarikwa na mitoK (ATP) umuyoboro wa 5-hydroxydecanoic aside ariko ntibibe hejuruK (ATP). Ingaruka zo guhagarika umuyoboro HMR1098. Nicorandil (100 mM) ibuza gutakaza ibyiza bya TUNEL, guhinduranya cytochrome C, gukora caspase-3, hamwe na mitochondrial membrane ubushobozi (Delta (Psi) (m)). Isesengura ry'utugingo ngengabuzima twandujwe na fluorescence Delta (Psi) (m) -indicator, tetramethylrhodamine Ethyl ester (TMRE) na fluorescence ikora selile yerekana ko, nicorandil irinda Delta (Psi) (m) gutandukana muburyo bushingiye ku kwibanda (EC (50) ) hafi mM 40, kwiyuzuza 100 mM). Muri selile zombi zahinduwe, Nicorandil yakoresheje intege nke imbere ikosora, glibenclamide-yunvikana 80 pS K. Muri selile HEK293T, Nicorandil ahitamo gukora umuyoboro wa K (ATP) urimo SUR2B. Nicorandil (100 mM) yabujije cyane umubare w'utugingo ngengabuzima twa TUNEL nziza kandi yongera ibikorwa bya mM 20 h2o2 iterwa na caspase-3. Kwishyira hamwe kwa Nicorandil birinda gutakaza DeltaPsim iterwa na H2O2.
Mu bushakashatsi bwa vivo Nicorandil (2,5 mg / kg buri munsi, po) ifatanije na Amlodipine (5.0 mg / kg buri munsi, po) iminsi itatu yibikorwa yabujije cyane impinduka kandi igarura ibikorwa bya enzyme kurwego ruri hafi yimbeba zisanzwe.

Ibicuruzwa birambuye

Ibicuruzwa

Ibimenyetso bya Hazard Xn - Byangiza
Kode y'ingaruka R22 - Byangiza niba byamizwe
R41 - Ibyago byo kwangirika cyane kumaso
Ibisobanuro byumutekano S26 - Mugihe uhuye namaso, kwoza ako kanya n'amazi menshi hanyuma ushakishe inama mubuvuzi.
S39 - Kwambara ijisho / kurinda amaso.
WGK Ubudage 3
RTECS US4667600
Kode ya HS 29333990
Uburozi LD50 mu mbeba (mg / kg): 1200-1300 mu kanwa; 800-1000 iv (Nagano)

 

Intangiriro

Nicolandil, izwi kandi nka nicorandil amine, ni ifumbire mvaruganda. Ibikurikira nintangiriro yumutungo, imikoreshereze, gutegura namakuru yumutekano ya nicorandil:

 

Ubwiza:

- Nicorandil nikintu gikomeye kitagira ibara rya kirisiti kibora mu mazi no mumashanyarazi.

- Numusemburo wa alkaline ushobora gukora na acide kugirango ubyare umunyu.

- Nikorandil ihagaze neza mu kirere, ariko irashobora kubora iyo ihuye n'ubushyuhe bwinshi.

 

Koresha:

- Nicolandil irashobora kandi gukoreshwa muri synthesis ya catalizike ya catalizike, ifotora, nibindi.

 

Uburyo:

- Ubusanzwe Nicolandil itegurwa nigisubizo cya dimethylamine hamwe na 2-karubone.

- Imyitwarire ikorwa mubihe bya alkaline kandi reaction yo gushyushya ikorwa mumashanyarazi akwiye.

 

Amakuru yumutekano:

- Nikorandil ifite umutekano muke kubantu mubihe rusange.

- Icyakora, hagomba kwitonderwa kugirango wirinde guhura n'amaso, uruhu, na sisitemu y'ubuhumekero.

- Kwambara ibikoresho bikingira umuntu (PPE) nkibirahure byumutekano, gants hamwe nibikoresho byo guhumeka.

- Mugihe ukoresha cyangwa ubika nicorandil, ugomba kwitonda kugirango wirinde gutwikwa nubushyuhe bwo hejuru.

 

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