tert-butyl 2 4-dioxopiperidine-1-carboxylate （CAS # 845267-78-9)

Inzira ya molekulari	C10H15NO4
Misa	213.23
Ubucucike	1.199
Ingingo ya Boling	373.8 ± 35.0 ° C (Biteganijwe)
Flash point	179.9 ° C.
Umwuka	8.72E-06mmHg kuri 25 ° C.
pKa	10.67 ± 0,20 (Byahanuwe)
Imiterere y'Ububiko	Komeza ahantu hijimye, Gufunzwe byumye, Ubushyuhe bwicyumba
Ironderero	1.493
MDL	MFCD10566071

Ibicuruzwa birambuye

Kode y'ingaruka	21/2/22 - Byangiza no guhumeka, guhura nuruhu kandi niba byamizwe.
Ibisobanuro byumutekano	S23 - Ntugahumeke umwuka. S24 / 25 - Irinde guhura nuruhu n'amaso.
WGK Ubudage	3
Kode ya HS	29337900

Koresha	2, 4-dipiperidon-1-igizwe na tert-butyl ni synthèse ya fenoxymethyl-dihydrothiazolopyridone ikomoka ku bicuruzwa, nkibintu byatoranijwe bihindura imiterere (PAM) ya reseptor ya glutamate 5 (mGlu5).
Porogaramu	2, 4-dioperidone-1-tert-butyl formate ikoreshwa cyane cyane hagati ya organic intermediate na farumasi hagati, kandi irashobora gukoreshwa mubushakashatsi bwa laboratoire niterambere ryiterambere hamwe nubuvuzi bwa chimique.
kwitegura	intambwe a: ongeramo EDCI (191.7g) kuri DMF (400mL) igisubizo cya 3- (tert-butoxycarbonylamino) aside protionic (189.2g, 1.0mol), aside meldamic (144.1g, 1.0mol) na DMAP (135.0g, 1.1mol ) gukonjeshwa no kwiyuhagira urubura, 1.0mol). Ibisubizo byavuyemo byabyutswe ijoro ryose ubushyuhe bwicyumba. Igisubizo cyazimye 200mL H2O. Imvange yavuyemo yongewemo buhoro kuri H2O (2.0L) munsi ya mashini. Ikomeye yabonetse yarayungurujwe kandi yozwa neza namazi kugeza kuri pH 7 kugirango ubone ibicuruzwa (283g, umusaruro wa 90%). Intambwe B: Igisubizo cya 3- (2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl) -3-oxopropylcarbamate tert-butyl ester (100g, 317.46mmol) muri toluene (1500mL) ashyushye kuri 100 ° C mu masaha 4. Imashini ikonjeshwa ubushyuhe bwicyumba kandi yibanda kumuvuduko muke kugirango ubone ibicuruzwa bitavanze. Ibicuruzwa (56g, umusaruro wa 83%) byahanaguwe na MTBE-gusya.